Open Positions

CeMM is an international and interdisciplinary research Center in Molecular Medicine installed by the Austrian Academy of Sciences. “From the clinic to the clinic”: Driven by medical needs, CeMM integrates basic research and clinical expertise to pursue innovative diagnostic and therapeutic approaches focused on cancer, inflammation and immune disorders. CeMM has a new tailor-made building at the center of the Vienna Medical University/General Hospital Campus and close to the heart of the city. Vienna has recently been ranked the #1 city of the world in terms of quality of life. The official language at CeMM is English. CeMM is an equal opportunity employer.

According to a study by “The Scientist”, CeMM is ranked as the best European place to work in Academia 2012, internationally CeMM appears at the fourth place, see: http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012

We are currently offering the following positions:

+ Technical Assistant
+ Biomedical Sequencing Facility: Bioinformatician and NGS Technologist
+ PostDoc in Medical Genomics/Epigenomics
+ ERC-funded PostDoc in Immunology and/or Genetics
+ Mitarbeiter/in für Rechnungswesen
+ Diploma Thesis in Bioinformatics: Analysis of Quantitative Proteomics
Data and Posttranslational Modification Dynamics

The Boztug Lab at CeMM seeks to fill the open positions of a
Technical Assistant (Reference code: #TA-KBo)

The focus of the group is on the identification of monogenetic defects of the immune system and their pathophysiologic consequences (for some recent publications see e.g Boztug K et al NEJM 2009; Glocker EO*, Kotlarz D*, Boztug K* et al NEJM 2009; Salzer E et al Blood 2013).
Kaan Boztug has recently been awarded the prestigious START Prize of the FWF – Austrian Science Fund and a Starting Grant of the ERC – European Research Council, the highest research prizes for young researchers in Austria and Europe.

The Boztug lab is a fully equipped molecular biology laboratory in a shared environment with cell culture and multi-color flow cytometry on the same floor within a brand new building. All equipment needed for state-of-the art genomic investigations such as SNP arrays and deep sequencing are immediately accessible on the same floor of the building. The group is embedded in a multidisciplinary and highly collaborative systems biology/molecular medicine research environment providing access to state-of-the-art mass-spectrometry, bioinformatics, automated chemical biological screening platform and animal facilities, including BSL2 suites. The group of Kaan Boztug works on the elucidation hitherto unkown inherited disorders of the hematological system with a focus on immunological disorders (so-called primary immunodeficiencies). The molecular investigation of the mechanisms underlying these disorders will improve understanding of the hierarchical organization of the immune system and also be an important step towards the development of novel therapeutic strategies for such patients. In the context of this work, the Boztug group applies a combination of genetic and genomic technologies including so-called next generation sequencing technologies along with a range of cell and molecular biological techniques.

The group is looking for a highly motivated and well-organized Technical Assistant who will be fully integrated into the scientific projects and will receive the necessary training to independently design, conduct and analyze experiments. In addition, the candidate is expected to contribute to the infrastructure and operation of the lab. This position offers the great opportunity to apply your skills for a better understanding of genetics, immunity and molecular medicine.

The successful applicant should have experience in a least two of the following areas:

A Bachelor degree in Life Science (or Magister/CTA/MTA), excellent interpersonal and organizational as well as good working knowledge of English are required.

Applicants should submit: A cover letter (why you are the ideal candidate for this position), a curriculum vitae and names and contact details of two suggested referees, to:application@cemm.oeaw.ac.at using the reference code: #TA-KBo.

Application Deadline: 15 May 2013

Biomedical Sequencing Facility:
Bioinformatician and NGS Technologist

We are looking for an experienced bioinformatician (computational) and a NGS technologist (wet-lab) to join the Biomedical Sequencing Facility at CeMM and the Medical University of Vienna.

The Biomedical Sequencing Facility [http://biomedical-sequencing.at/]
CeMM and the Medical University of Vienna (MUV) recently joined forces and launched the Biomedical Sequencing Facility (BSF), which is coordinated by CeMM Principal Investigator Christoph Bock. The goals of the BSF are to foster biomedical research and to catalyze the development of genomic medicine in Vienna and Austria. The BSF is currently equipped with two Illumina HiSeq 2000 sequencers and a high-throughput robotics pipeline for automated library preparation. Further machine purchases are planned for 2013/2014. The BSF is also supported by a powerful scientific computing cluster, which is upgraded annually to keep pace with strongly increasing amounts of biomedical data. Genomics protocols that are routinely run by the BSF include: whole-genome sequencing, exome sequencing, epigenome mapping by ChIP-seq and whole-genome bisulfite sequencing, and transcriptome mapping by various forms of RNA-seq. Furthermore, the BSF collaborates with clinical labs at the MUV toward establishing genome sequencing as part of clinical diagnostics.

Associated Labs at CeMM

The Candidate
We are looking for highly motivated candidates with a strong interest in contributing the genomics revolution of biomedicine. For the experienced bioinformatician we require excellent academic training and research experience in bioinformatics (typically evidenced by a PhD degree, but candidates with a Bachelor or Master degree and relevant work experience in industry are also eligible), strong programming skills and hands-on experience working with large datasets. For the NGS Technologist we are looking for candidates with a degree in molecular biology or medical diagnostics and substantial hands-on experience with DNA-based assays and high-throughput technologies. For both positions, we aim to provide a longer-term employment perspective. Finally, given that CeMM works in highly competitive areas at the forefront of global biomedical research, intellectual curiosity, flexibility and dedication to science are major success factors for any candidate.

Application DetailsPlease submit cover letter, curriculum vitae, academic transcripts and contact details of three referees to application@cemm.at. Please indicate the reference code in the subject line: BSF Bioinformatician or BSF Technologist.

Deadline for Applications: 31 May 2013

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PostDoc in Medical Genomics/Epigenomics

We are looking for an enthusiastic postdoc with bioinformatic or wet-lab focus (or a combination) to join the Medical Epigenomics Lab at CeMM. Our group combines experimental and computational methods for understanding epigenome regulation in cancer, stem cells, and immune diseases.

The Lab [http://www.medical-epigenomics.org/]
The lab combines large-scale analysis of the epigenome with stem cell biology and computational modeling, in order to better understand and treat leukemia and other diseases of the blood system. We work closely with biologists and medical researchers at the Medical University of Vienna, aiming to advance personalized medicine through epigenome sequencing and bioinformatic innovation. Specific research interests include (but are not limited to):

The Principal Investigator [http://christoph-bock.org/]
Christoph Bock received his training in computer science and business science from the Universities of Mannheim and Heidelberg (Germany). He obtained a PhD in bioinformatics from the Max Planck Institute for Informatics, for which he was awarded an Otto Hahn Medal by the Max Planck Society. Christoph did his postdoc in epigenome research at the Broad Institute of MIT and Harvard, contributing to the Roadmap Epigenomics Project. In parallel, Christoph led a research group on computational epigenetics at the Max Planck Institute for Informatics. His recent publications include papers in Cell, Molecular Cell, Nature Biotechnology, Nature Methods, Nature Reviews Cancer, Nature Reviews Genetics, Genome Research, Genome Biology, PLoS Computational Biology, Bioinformatics and Science (http://scholar.google.com/citations?user=9qSsTcIAAAAJ). Christoph also co-directs a next generation sequencing platform in Vienna (http://biomedical-sequencing.at), he is a guest professor at the Medical University of Vienna and a work package leader in the European epigenome mapping project (http://blueprint-epigenome.eu).

The Project
The lab is driven by the ideas of all its members. If you already have a project in mind, we would like to hear from you. If not, here are a few topics for inspiration: (i) Why is leukemia a disease of the elderly? Can we identify an “epigenetic clock” that counts down toward leukemia? What is wrong with this clock in those rare cases of childhood leukemia? (ii) Can we construct a blood cancer from scratch, by inducing only epigenetic defects? Which combination of pathways provides the minimum core of an epigenetic leukemia? (iii) How can we make epigenome data useful for personalized medicine? Every physician uses Google – can we build a “Google for the epigenome”? (iv) How can we design epigenetic drug therapies that keep resistance at bay?

The Candidate
We are looking for highly motivated and academically outstanding candidates who want to pursue a scientific career in the emerging field of medical epigenomics. An ideal candidate would have a background in molecular biology (or human genetics, genomics, molecular medicine, etc.) or a computational discipline (bioinformatics, physics, engineering, etc.) and a strong interest in working together with collaborators in the entire spectrum of epigenetics, medical genomics and bioinformatics.

Application Details
Please submit cover letter, curriculum vitae, academic transcripts and contact details of three referees to application@cemm.at. Please indicate the reference code Postdoc Medical Epigenomics in the subject line.

Deadline for Applications: 31 May 2013

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ERC-funded Post-doctoral Fellowship in Immunology
and/or Genetics (Reference Code: #PO-KBo3)

The Boztug laboratory at CeMM seeks to fill the open position of a Post-Doctoral Fellow (junior or senior level). The focus of the group is on the identification of Mendelian defects of the immune system and their pathophysiologic consequences (for some recent publications see e.g., Boztug K et al NEJM 2009; Glocker EO*, Kotlarz D*, Boztug K* et al NEJM; Salzer E et al Blood 2013).

The Project:
The successful candidate will use high throughput genomics approaches including high-resolution SNP arrays and deep sequencing as well as functional proteomics of protein complexes to mine, uncover and pathway-map gene defects underlying inherited disorders of the immune system (primary deficiencies) with high efficiency. This discovery pipeline is complemented by biochemical, immunological and imaging technologies to obtain molecular gene-to-phenotype relationships. The proposed investigations will contribute significantly to our understanding of the molecular processes that structure our immune system. Several specific projects are available in the lab, in addition own project proposals which match the lab`s focus are welcome.

The Principal Investigator:
Dr. Boztug studied Medicine at the Universities of Düsseldorf, Freiburg and London and worked on his medical thesis (“summa cum laude”) at The Scripps Research Institute, La Jolla, CA, USA and the University Hospital Freiburg, Department of Neuropathology. He gained medical training in Pediatrics and postdoc experience in the Department of Pediatric Hematology/Oncology at the Hannover Medical School. He completed his “Habilitation” in Experimental Hematology at Hannover Medical School in 2010. Dr. Boztug has a first-class training and an impressive academic record decorated with honors and prizes, including a Merit Award from the American Society of Hematology and the Eva Luise and Horst Köhler Prize for Research in Rare Diseases. Dr. Boztug has a joint appointment as a Visiting Professor at the Department of Paediatrics and Adolescent Medicine at the Medical University of Vienna, Europe’s largest University Hospital. He has recently been awarded the prestigious START Prize of the Austrian Science Fund, the highest and most well-funded research prize for young researchers in Austria, as well as a Starting Grant of the European Research Council (ERC), which will enable well-funded research at a world-class level in his laboratory at CeMM.

The Boztug Lab:
is a fully equipped molecular biology laboratory in a shared environment with cell culture and multi-color flow cytometry on the same floor within a brand new building. All equipment needed for state-of-the art genomic investigations such as SNP arrays and deep sequencing are immediately accessible on the same floor of the building. The group is embedded in a multidisciplinary and highly collaborative systems biology/molecular medicine research environment providing access to state-of-the-art mass-spectrometry, bioinformatics, automated chemical biological screening platform and animal facilities, including BSL2 suites.

The Candidate:
Interested candidates should have a strong background in Immunology, Genetics and/or Molecular Biology and need to have a PhD (respectively DVM/MD or equivalent) degree. Candidates who are just about to finish their doctoral studies are also very welcome to apply. The ideal candidate features excellent work ethics and communication skills. Enthusiasm, self-motivation, creativity as well as a proactive stance on solving problems and developing new ideas are wanted. We seek a candidate who is able to connect different scientific disciplines and to think outside the box. As we have recently identified several novel genetic defects causing primary immunodeficiencies, this position may enable you to make a leap in your academic career!

Applicants should submit:
Please send your application to application@cemm.at using the reference code #PO-KBo3. Your full application includes your CV, the contact details of your PhD supervisor and two additional referees as well as a detailed letter of motivation.

Deadline for applications:
Initial Deadline: 5 May 2013, but the call will remain open until the position is filled.

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CeMM, das Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften, ist eine internationale Einrichtung (GmbH), in der medizinische Spitzenforschung betrieben wird, mit dem Ziel, eine personifizierte, vorbeugende und patientengerechtere Medizin des 21. Jahrhunderts zu gestalten.

Zur Verstärkung unseres Teams suchen wir
eine/n Mitarbeiter/in für unser RECHNUNGSWESEN

Es erwarten Sie folgende Aufgaben:

Allgemeine Rechnungsbearbeitung (Kontrolle, Kontierung, Rechnungseingangsbuch)
Spesenabrechnungen
Erstellung und Verbuchung von Ausgangsrechnungen
Kontenabstimmungen
Laufende Anlagenbuchhaltung
Abschlussarbeiten (Monats- und Jahresabschluss)
Mitarbeit bei der Drittmittelabrechnung
Unterstützung des Finanz-Teamleiters

Mit folgendem Profil überzeugen Sie uns:

Abgeschlossene kaufmännische Ausbildung (überdurchschnittlich guter Lehrabschluss/HASCH/HAK/HLW/Wifi oder KWT Buchhalterprüfung)
Berufserfahrung
Gute MS-Office-Kenntnisse, wobei sehr gute Excel-Kenntnisse Voraussetzung sind
Ausgezeichnete Deutschkenntnisse und sehr gute Englischkenntnisse
Zuverlässigkeit und Pünktlichkeit
Engagement und ein genauer, strukturierter Arbeitsstil

Wir wenden uns mit dieser Ausschreibung vor allem an Personen, die sich durch eine hohe Serviceorientierung auszeichnen, gerne Englisch sprechen und Teil eines sehr internationalen, jungen Teams sein möchten.

Wir bieten:
Ein kompetitives Bruttomonatsentgelt von € 2.000 bis € 2.400 (je nach Erfahrung und Qualifikation). Ihre Nettoarbeitszeit beträgt 40 Std/Woche, wobei wir Gleitzeit anbieten.

CeMM wurde von The Scientist zu Europas “Best Place to Work in Academia 2012” gewählt. In unserem Institut erwartet Sie ein wertschätzendes und angenehmes Arbeitsklima, ein moderner Arbeitsplatz mit guter öffentlicher Anbindung sowie gelebtes Diversity Management. Darüber hinaus bieten wir allen unseren Mitarbeiterinnen und Mitarbeitern die Möglichkeit, ihre Fähigkeiten auszubauen und weiterzuentwickeln und spannende Forschung an vorderster Front mitzuerleben.

Details für Ihre Bewerbung:
Bitte senden Sie Ihre aussagekräftigen Bewerbungsunterlagen (Motivationsschreiben, Lebenslauf, Abschluss- und Dienstzeugnisse sowie Kontaktdaten von zumindest einer Referenzperson) per E-Mail bis spätestens 30.04.2013 an Frau Binia Maria Günther: application@cemm.at
Wir freuen uns noch heute von Ihnen zu hören!

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DIPLOMA THESIS: Analysis of Quantitative Proteomics Data and Posttranslational Modification Dynamics

At CeMM, the traditional paradigm of biomedical research (basic research results finding their way toward medical applications through a long process of trial-and-error) is challenged by a more integrative and systems-level approach, in which bioinformatics plays a key role.

CeMM has established a world-class quantitative proteomics and mass spectrometry platform that is used to measure and compare the expression of proteins, quantify posttranslational modification dynamics, and to perform protein interaction experiments in a differential manner. The large quantitative datasets are analyzed with isobar (Breitwieser et al, Journal Proteome Res, 2011), an R Bioconductor package actively developed at CeMM, which implements advanced statistical models to determine significant protein regulation, combine replicates, etc.
The project consists in developing a user friendly interface to isobar by means of web-based technologies to facilitate isobar use for non bioinformaticians. Interaction with international collaborators who participated in isobar development is expected. Depending on the development of the diploma thesis, extensions towards downstream functional analyses such as biological pathway enrichment will be considered. In this case, the focus will be on linking isobar with existing Bioconductor packages and rendering their output.

Support from the bioinformatics department will be provided as well as contact and interaction with the mass spectrometry department. Successful completion of the project should lead to a technical paper first authored by the student and substantial experience in using R as a bioinformatics environment.

We are looking for a motivated student (molecular biology, mathematics, physics, computer science) with solid computer programming skills (HTML, CSS, JavaScript, server side programming, user interface design, knowledge of R would be a plus). Starting day is flexible but a date between June and September would be preferred.

Contact: Interested students should send their application or questions to Jacques Colinge (jcolinge@cemm.oeaw.ac.at). The successful candidates will be paid according to FWF standards.

Deadline for Applications:
We accept applications until the position is filled.